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Borrelidin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Borrelidin图片
CAS NO:7184-60-3
包装与价格：
包装价格(元)
500ug电议
1mg电议

产品介绍
Borrelidin (Treponemycin) 是一种细菌和真核生物苏氨酰-tRNA 合成酶抑制剂，是一种从罗氏链霉菌中分离出来的含腈大环内酯类抗生素。
Cas No.7184-60-3
别名疏螺旋体素,Treponemycin
化学名(1R,2R)-2-((2S,4E,6E,8R,9S,11R,13S,15S,16S)-7-cyano-8,16-dihydroxy-9,11,13,15-tetramethyl-18-oxooxacyclooctadeca-4,6-dien-2-yl)cyclopentanecarboxylic acid
Canonical SMILESOC([C@H]1[C@H]([C@H](C/C=C/C=C(C#N)/[C@@H]([C@@H](C)C[C@H](C)C[C@H](C)C[C@H](C)[C@H](C2)O)O)OC2=O)CCC1)=O
分子式C28H43NO6
分子量489.64
溶解度Chloroform: Soluble,DMSO: Soluble,Methanol: Soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor which is a nitrile-containing macrolide antibiotic isolated from Streptomyces rochei[1]. Borrelidin (Treponemycin) is an inhibitor of Cdc28/Cln2 of the budding yeast, with an IC50 of 24 μM[2]. Borrelidin (Treponemycin) is a potent angiogenesis inhibitor, with an IC50 of 0.8 nM, and induces apoptosis of the tube-forming cells. Borrelidin (Treponemycin) has strong antimalarial activities, with IC50s of 1.9 nM and 1.8 nM against K1 and FCR3 strains of Plasmodium falciparum[3].

Borrelidin (Treponemycin) can target ALL cell lines and induce apoptosis and mediating G(1) arrest.

References:
[1]. Habibi D, et al. Borrelidin, a small molecule nitrile-containing macrolide inhibitor of threonyl-tRNA synthetase, is a potent inducer of apoptosis in acute lymphoblastic leukemia. Invest New Drugs. 2012 Aug;30(4):1361-70.
[2]. Tsuchiya E, et al. Borrelidin inhibits a cyclin-dependent kinase (CDK), Cdc28/Cln2, of Saccharomyces cerevisiae. J Antibiot (Tokyo). 2001 Jan;54(1):84-90.
[3]. Wakabayashi T, et al. Borrelidin is an angiogenesis inhibitor; disruption of angiogenic capillary vessels in a rat aorta matrix culture model. J Antibiot (Tokyo). 1997 Aug;50(8):671-6.
[4]. Otoguro K, et al. In vitro and in vivo antimalarial activities of a non-glycosidic 18-membered macrolide antibiotic, borrelidin, against drug-resistant strains of Plasmodia. J Antibiot (Tokyo). 2003 Aug;56(8):727-9.