包装 | 价格(元) |
10mM (in 1mL DMSO) | 电议 |
200mg | 电议 |
500mg | 电议 |
Cell lines | ALVA-41, PC-3, and BPH-1 cells |
Preparation Method | For cell viability studies, ALVA-41, PC-3, and BPH-1 cells were treated for 24 h with 10 µmol/L and 100 µmol/L concentrations of resveratrol or EGCG. |
Reaction Conditions | 10, 100 µM for 24 hours |
Applications | Resveratrol at low doses (10 µmol/L) induced a proliferative response in ALVA-41 and BPH-1 cells at 24 h, which was not evident in PC-3 cells. However, at a higher dose (100 µmol/L), resveratrol produced a significant toxicity in prostate cancer cells, although the effect on ALVA-41 cells was relatively greater than on PC-3 cells. |
Animal models | CB17SC mice model injected with LAPC-4 cells |
Preparation Method | In the primary LAPC-4 study, mice were fed no resveratrol (control), 50 mg/kg/day resveratrol (RV50), or 100 mg/kg/day resveratrol (RV100). |
Dosage form | Fed in diet, 50 mg/kg/day and 100 mg/kg/day |
Applications | In the LAPC-4 study, RV50 significantly decreased survival while RV100 did not significantly change survival. |
产品描述 | Resveratrol (trans-Resveratrol; SRT501) is a phytoalexin. Resveratrol is a potent reducing agent, and can prevent carcinogenesis due to its anti-oxidant abilities[1]. Resveratrol has a broad range of targets, including cyclooxygenase (e.g., COX, IC50=1.1 μM), lipoxygenase (LOC, IC50=2.7 μM), STAT3 (IC50=20 μM), and other proteins[2,3]. Resveratrol treatment is found to exert its effect on renal cell carcinoma (RCC) proliferation, migration and invasion in a concentration dependent manner through inactivation of the Akt and ERK1/2 signaling pathways[4]. In CaCo-2 cells, treatment with 25 μM Resveratrol has shown 70% growth inhibition due to S/G2 phase arrest[5]. Resveratrol treatment lead to inhibited invasion and metastasis of colorectal cancer-derived cell lines LoVo and HCT116 by suppressing the Wnt/β-catenin signaling mediated target genes of c-Myc, MMP-7, and MALT-1[6]. Resveratrol is shown to be effective against breast cancer metastasis to lungs in mice by its inhibitory effect on Stat3 mediated signaling[7]. Resveratrol treatment reduced size and number of tumor spheres in renal carcinoma stem cells xenograft mice model [8]. Resveratrol treatment reduced Epithelial to mesenchymal transition (EMT) of glioblastoma U87 xenografted mice models[9]. References: |