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4-hydroperoxy Cyclophosphamide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
4-hydroperoxy Cyclophosphamide图片
CAS NO:39800-16-3
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍

化学性质

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt293.08
Cas No.39800-16-3
FormulaC7H15Cl2N2O4P
SolubilitySoluble in chloroform
Chemical Name2-(bis(2-chloroethyl)amino)-4-hydroperoxy-1,3,2-oxazaphosphinane 2-oxide
Canonical SMILESO=P1(N(CCCl)CCCl)OCCC(OO)N1
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

4-hydroperoxy Cyclophosphamide is the active metabolite form of the prodrug Cyclophosphamide. It crosslinks DNA and induces T cell apoptosis independent of death receptor activation, but activates mitochondrial death pathways through production of reactive oxygen species (ROS)[1]. Formulations containing the prodrug Cyclophosphamide are used to treat lymphomas and autoimmune disorders[2,3].

References:

[1]. Strauss G, Westhoff M A, Fischer-Posovszky P, et al. 4-hydroperoxy-cyclophosphamide mediates caspase-independent T-cell apoptosis involving oxidative stress-induced nuclear relocation of mitochondrial apoptogenic factors AIF and EndoG. Cell Death Differ, 2008, 15(2): 332-343.

[2]. Ahmed A R, Hombal S M. Cyclophosphamide (Cytoxan). A review on relevant pharmacology and clinical uses. J. Am. Acad. Dermatol, 1984, 11(6): 1115-1126.

[3]. Appel G B. New and future therapies for lupus nephritis. Cleve. Clin. J. Med, 2012, 79(2): 134-140.