CAS NO: | 67605-85-0 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 171.19 |
Cas No. | 67605-85-0 |
Formula | C8H13NO3 |
Solubility | ≥43.4 mg/mL in DMSO; ≥53.6 mg/mL in EtOH; ≥43.6 mg/mL in H2O |
Chemical Name | (S)-N-(2-oxotetrahydrofuran-3-yl)butyramide |
Canonical SMILES | CCCC(N[C@H]1CCOC1=O)=O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
N-butyryl-L-Homoserine lactone is a small diffusible signaling molecule involved in quorum sensing (QS) [1].
QS is a way of cell-to-cell communication that utilizes diffusible signaling molecules sensed by the population to determine population density, thus coordinating gene regulation in response to population density. The various potential applications of N-butyryl-L-Homoserine lactone includes virulence regulation, infection prevention, and biofilm formation [1]. In addition, N-butyryl-L-Homoserine lactone may also act as an elicitor from bacteria in plant [2].
In the excised root cells of Arabidopsis plants, 10 μM N-butyryl-L-Homoserine lactone induced a transient and immediate increase in the cytosolic free Ca2+ concentration ([Ca2+]cyt), the highest level of which was 0.4 μM, approximately 2-fold higher than the basal level. Pretreatments of verapamil, La3+ or ethylene glycol tetraacetic acid (EGTA) reversed the increase in [Ca2+]cyt triggered by N-butyryl-L-Homoserine lactone, whilst it remained unaffected by pretreatment with Li+, indicating that the Ca2+ contributing to the increase in [Ca2+]cyt was transferred from the extracellular medium via the plasma membrane Ca2+ channels but not from the intracellular Ca2+ storage. Furthermore, N-butyryl-L-Homoserine lactone significantly increased the transmembrane Ca2+ current [2].
References:
[1]. Wu D, Huang W, Duan Q, et al. Sodium houttuyfonate affects production of N-acyl homoserine lactone and quorum sensing-regulated genes expression in Pseudomonas aeruginosa. Frontiers in Microbiology, 2014, 5(635): 1-9.
[2]. Song S, Jia Z, Xu J, et al. N-butyryl-homoserine lactone, a bacterial quorum-sensing signaling molecule, induces intracellular calcium elevation in Arabidopsis root cells. Biochemical and Biophysical Research Communications, 2011, 414(2): 355-360.