| CAS NO: | 1032508-03-4 |
| 包装 | 价格(元) |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 274.7 |
| Cas No. | 1032508-03-4 |
| Formula | C16H15ClO2 |
| Solubility | ≤2mg/ml in ethanol;20mg/ml in DMSO;30mg/ml in dimethyl formamide |
| Chemical Name | (E)-5-[2-(4-chlorophenyl)ethenyl]-1,3-dimethoxyphenyl |
| Canonical SMILES | ClC(C=C1)=CC=C1/C=C/C2=CC(OC)=CC(OC)=C2 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
PDM 11 is a potent and selective aryl hydrocarbon receptor (AhR) antagonist.
Aryl hydrocarbon receptor (AhR), a ligand-dependent intracellular transcription factor, has ligands including the most infamous xenobiotics, such as benzo[a]pyrene, dioxin, and plenty of polyaromatics.
In vitro: In a previous study, PDM 11 was found to be structurally very similar to several resveratrol analogs which acted as a potent and selective AhR antagonists and agonists. One of these compounds with fluorine in place of the 4'-chlorine of PDM11 was shown to act as a AhR antagonist with a Ki of about 3 nM. This fluorine-containing compound was found to be inactive as a ligand for the estrogen receptor at even up to 100 μM. Therefore, since AhR knockout mice have been reported to be insensitive to the carcinogenic effects of classical AhR ligands, antagonists of AhR might potentially serve as therapeutic agents for the treatment for dioxin and other aryl hydrocarbon poisonings [1].
In vivo: Up to now, there is no animal in vivo data reported.
Clinical trial: So far, no clinical study has been conducted.
Reference:
[1] de Medina, P. ,Casper, R.,Savouret, J.F., et al. Synthesis and biological properties of new stilbene derivatives of resveratrol as new selective aryl hydrocarbon modulators. Journal of Medicinal Chemistry 48, 287-291 (2005).
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