| CAS NO: | 893449-38-2 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -80°C |
| M.Wt | 485.2 |
| Cas No. | 893449-38-2 |
| Formula | C17H11Br2NO2S2 |
| Synonyms | BR-1,P0108,Phosphatase of Regenerating Liver 3 Inhibitor,PTP4A3 Inhibitor |
| Solubility | ≤16mg/ml in DMSO;16mg/ml in dimethyl formamide |
| Chemical Name | 5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone |
| Canonical SMILES | BrC1=CC=C(OCC2=C(Br)C=CC=C2)C(/C=C3C(NC(S\3)=S)=O)=C1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
IC50: 900 nM: blocks human phosphatase of regenerating liver 3 (PRL-3) in vitro.
PRL-3 inhibitor, a cell-permeable benzylidene rhodamine compound, potently dampens PRL-3 and inhibits other phosphatases with minimal activity. It has been demonstrated that PRL-3 inhibitor can be used as therapeutics for the treatment of cancer. PRL-3 is a member of the regenerating liver family tyrosine phosphatases and plays vital roles in cell proliferation, migration, invasion, and motility, and thus leads to cancer metastasis.
In vitro: PRL-3 inhibitor, in a dose-dependent fashion, blocked the dephosphorylation of DiFMUP by PRL-3 and strongly suppressed the activity of PRL-3 phosphatase in PRL-3 overexpressing DLD-1 colon tumor cells [DLD-1 (PRL-3)]. Also, PRL-3 inhibitor dose-dependently blocked the migration of DLD-1 (PRL-3) cells, however, it did not inhibit the proliferation of DLD-1(PRL-3) cells, suggesting that PRL-3 inhibitor significantly blocked cell immigration and invasion without cytotoxicity [1].
In vivo: Up to now, in vivo study of PRL-3 Inhibitor is still in the development stage.
Reference:
[1]. Min, G., Lee, S., Kim, H., Han, Y., Lee, R., & Jeong, D. et al. Rhodanine-based PRL-3 inhibitors blocked the migration and invasion of metastatic cancer cells. Bioorganic & Medicinal Chemistry Letters. 2013; 23(13): 3769-3774.
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