| CAS NO: | 142128-47-0 |
| 包装 | 价格(元) |
| 50mg | 电议 |
| 500mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 313.5 |
| Cas No. | 142128-47-0 |
| Formula | C19H39NO2 |
| Synonyms | R-1 PMA |
| Solubility | ≤10mg/ml in ethanol;25mg/ml in DMSO;3.3mg/ml in dimethyl formamide |
| Chemical Name | N-(2-hydroxy-1R-methylethyl)-hexadecanamide |
| Canonical SMILES | CCCCCCCCCCCCCCCC(=O)N[C@H](C)CO |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
R-Palmitoyl-(1-methyl) ethanolamide, a synthetic analog of Palmitoyl ethanolamide (PEA), incorporates the (R)-methyl group vicinal to the alcohol on the ethanolamine moiety. The analogous modification to arachidonoyl ethanolamide (AEA) protects the molecule from hydrolysis by fatty acid amide hydrolase, prolongs duration of action and enhances potency in vivo [1].
PEA is an endogenous cannabinoid existed in mammalian tissues, such as liver and brain. PEA has also been isolated from egg yolk [2, 3]. PEA is a compound with documented anti-nociceptive and anti-inflammatory effects. During inflammation, PEA is accumulated and exihibits anti-inflammatory effects, including beneficial effects in clinically relevant animal models of inflammatory pain [4].
References:
[1] Abadji V, Lin S, Taha G, et al. (R)-methanandamide: a chiral novel anandamide possessing higher potency and metabolic stability[J]. Journal of medicinal chemistry, 1994, 37(12): 1889-1893.
[2] Bachur N R, Masek K, Melmon K L, et al. Fatty acid amides of ethanol-amine in mammalian tissues[J]. Journal of Biological Chemistry, 1965, 240: 1019-1024.
[3] Ganley O H, Graessle O E, Robinson H J, et al. Anti-inflammatory activity of compounds obtained from egg yolk, peanut oil, and soybean lecithin[J]. Journal of Laboratory and Clinical Medicine, 1958, 51: 709-714.
[4] Lambert D M, Vandevoorde S, Jonsson K O, et al. The palmitoylethanolamide family: a new class of anti-inflammatory agents [J]. Current medicinal chemistry, 2002, 9(6): 663-674.
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