| CAS NO: | 579-56-6 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 10g | 电议 |
| Storage | Store at -20°C |
| M.Wt | 337.8 |
| Cas No. | 579-56-6 |
| Formula | C18H23NO3·HCl |
| Solubility | insoluble in H2O; insoluble in EtOH; ≥16.3 mg/mL in DMSO |
| Chemical Name | 4-hydroxy-α-[1-[(1-methyl-2-phenoxyethyl)amino]ethyl]-benzenemethanol, monohydrochloride |
| Canonical SMILES | OC1=CC=C(C(O)C(C)NC(C)COC2=CC=CC=C2)C=C1.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Isoxsuprine is a modulator of β2 adrenoreceptor and has agonist or antagonist effects.
The β2 adrenoceptors are a class of G protein-coupled receptors that are targets for epinephrine. Many cells possess these receptors, the binding of epinephrine to the receptor will generally stimulates the sympathetic nervous system, resulting in muscle relaxation, vasodilation, diverting blood flow from non-essential organs to skeletal muscle and mobilizing energy [1].
As a modulator of β2 adrenoreceptor, Isoxsuprine is used as a vasodilator as well as smooth muscle modifier in humans. In vitro neuroprotection experiment, when administered up to an hour after reoxygenation, Isoxsuprine demonstrated no loss of neuron efficacy [2]..
In vivo animal stroke model, 1 mg/kg isoxsuprine was administered after a 90-minute occlusion of the right middle cerebral artery by IV injection at reperfusion. Total infarct volume in isoxsuprine-treated group was 137±18 mm3 compared to 279±25 mm3 in control group [2].
References:
1. R. S. Ekert and C. G. Macallister. Isoxsuprine hydrochloride in the horse: A review. J. Vet. Pharmacol. Ther. 2002, 25(2), 81-87
2. Hill JW, Thompson JF, Carter MB. Identification of isoxsuprine hydrochloride as a neuroprotectant in ischemic stroke through cell-based high-throughput screening. PLoS One. 2014 May 7; 9(5):e96761
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