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6H05 trifluoroacetate(K-Ras inhibitor)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
6H05 trifluoroacetate(K-Ras inhibitor)图片
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
2mg电议
5mg电议
10mg电议

产品介绍
6H05三氟醋酸盐是突变型原癌基因K-ras(G12C)选择性变构抑制剂。
Canonical SMILESO=C(C1CCN(C(CSC2=CC=C(Cl)C=C2)=O)CC1)NCCSSCCN(C)C.O=C(O)C(F)(F)F
分子式C22H31ClF3N3O4S3
分子量590.14
溶解度DMSO : ≥ 51 mg/mL (86.42 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

6H05 trifluoroacetate is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C). IC50 value:Target: K-Ras G12C6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras [1]. 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors [2].

[1]. Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-51. [2]. Lu S, et al. Harnessing allostery: a novel approach to drug discovery. Med Res Rev. 2014 Nov;34(6):1242-85.