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K-41
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
K-41图片
CAS NO:53026-37-2
包装:1mg
市场价:2797元

产品介绍
A fungal metabolite with antibiotic and antiparasitic activities
Cas No.53026-37-2
Canonical SMILESCO[C@@H]1C[C@](C[C@H]2[C@@](OC)(C)[C@@H](OC)[C@H](C)[C@]([C@H](C(O)=O)O)(O)O2)([H])O[C@]3(O[C@@]([C@@]4([H])CC[C@]([C@]5([H])O[C@]([C@]6([H])[C@@H](C)[C@H](O[C@@H]7O[C@H](C)[C@@H](OC)CC7)[C@@H](C)[C@](O)(C)O6)([H])CC5)([H])O4)(C)[C@H](OC)[C@H]3C)[C@@H]1C
分子式C48H82O18
分子量947.2
溶解度Dichloromethane: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

K-41 is a monoglycoside polyether fungal metabolite originally isolated fromS. hygroscopicusthat has antibiotic and antiparasitic activities.1,2It is active againstB. subtilis,B. anthracis,S. aureus,S. pyogenes,S. pneumoniae,C. diphtheriae, andM. tuberculosis(MICs = 3.13, 1.56, 1.56, 0.78, 0.39, 0.78, and 3.13 µg/ml, respectively).1K-41 is active against the K1 drug-resistant and FCR3 drug-susceptibleP. falciparumstrains (IC50s = 8.5 and 31 nM, respectively).2In vivo, K-41 has antiparasitic activity in mouse models ofP. bergheiandP. yoeliiinfection (ED50s = 1.9 and 7.0 mg/kg, respectively).

1.Tsuji, N., Nagashima, K., Kobayashi, M., et al.Two new antibiotics, A-218 and K-41. Isolation and characterizationJ. Antibiot. (Tokyo)29(1)10-14(1976) 2.Moreno, M., and Giralt, E.Three valuable peptides from bee and wasp venoms for therapeutic and biotechnological use: Melittin, apamin and mastoparanToxins71126-1150(2015)