CAS NO: | 1049731-36-3 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
Physical Appearance | A crystalline solid |
Storage | Store at -20°C |
M.Wt | 479.91 |
Cas No. | 1049731-36-3 |
Formula | C22H34N4O·3HCl |
Solubility | Soluble to 100 mM in sterile water |
Chemical Name | N-(3-((4-((3-aminopropyl)amino)butyl)amino)propyl)-2-(naphthalen-1-yl)acetamide trihydrochloride |
Canonical SMILES | O=C(CC1=CC=CC2=CC=CC=C12)NCCCNCCCCNCCCN.Cl.Cl.Cl |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
Naspm trihydrochloride is a selective antagonist of Ca2+-permeable α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA) receptors. AMPA receptors are glutamate-gated ion channels that play central roles in the mammalian brain, mediating fast excitatory synaptic transmission and underlying several forms of synaptic plasticity. On excitatory neurons in adult animals, two types of AMPA receptors are primarily expressed, namely heteromeric channels composed of GluR1 and GluR2 subunits (GluR1/2 receptors), as well as channels composed of GluR2 and GluR3 subunits (GluR2/3 receptors). Naspm trihydrochloride blocks AMPA receptors lacking the GluR2 subunit, with an IC50 value of 0.3 μM for GluR1 homomers.
References:
1. Nilsen A, England PM. A subtype-selective, use-dependent inhibitor of native AMPA receptors. Journal of the American Chemical Society, 2007, 129(16): 4902-4903.
2. Koike M, Iino M, Ozawa S. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neuroscience Research, 1997, 29(1): 27-36.
Cell experiment:[2] | |
Cell lines | Rat hippocampal neurons |
Reaction Conditions | 0.01 ~ 10 μM Naspm trihydrochloride |
Applications | Naspm trihydrochloride (3 μM) selectively inhibited the strong inward rectification and Ca2+-permeable AMPA receptors expressed in type Ⅱ neurons, but showed no effect on AMPA receptors in type Ⅰ neurons. At -60 mV, Naspm trihydrochloride suppressed AMPA receptors in type Ⅱ neurons, with an IC50 value of 0.33 μM. The blocking effect of Naspm trihydrochloride on the Ca2+-permeable AMPA receptors was dose- and voltage-dependent. |
Note | The technical data provided above is for reference only. |
References: 1. Nilsen A, England PM. A subtype-selective, use-dependent inhibitor of native AMPA receptors. Journal of the American Chemical Society, 2007, 129(16): 4902-4903. 2. Koike M, Iino M, Ozawa S. Blocking effect of 1-naphthyl acetyl spermine on Ca2+-permeable AMPA receptors in cultured rat hippocampal neurons. Neuroscience Research, 1997, 29(1): 27-36. |