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(1α,1'S,4β)-Lanabecestat
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
(1α,1'S,4β)-Lanabecestat图片
CAS NO:1384082-96-5
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
2mg电议
5mg电议
10mg电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
(1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) 是一种 BACE1 抑制剂,IC50 分别为 2.2 nM (TR-FRET 测定) 和 0.28 nM (sAPPp 释放测定),详细信息请参考专利文献 WO2012087237A1 中的化合物 20a。
Cas No.1384082-96-5
别名(1α,1'S,4β)-AZD3293; (1α,1'S,4β)-LY3314814
Canonical SMILESNC(C(C)=N1)=N[C@]21C3=C(C=CC(C4=CC(C#CC)=CN=C4)=C3)C[C@]52CC[C@@H](OC)CC5
分子式C26H28N4O
分子量412.53
溶解度DMSO: 250 mg/mL (606.02 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(1α,1'S,4β)-Lanabecestat ((1α,1'S,4β)-AZD3293) is a Beta site APP Cleaving Enzymel (BACE1) inhibitor extracted from patent WO2012087237A1, compound 20a, has IC50s of 2.2 nM (TR-FRET assay) and 0.28 nM (sAPPp release assay), respectively[1].

[1]. Gabor Csjernyik, et al. Compounds and their use as bace inhibitors. WO2012087237A1.