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Tyramine-d4(hydrochloride)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Tyramine-d4(hydrochloride)图片
CAS NO:1189884-47-6
包装:5mg
市场价:8996元

产品介绍
 
Cas No.1189884-47-6
别名盐酸酪胺 d4 (盐酸盐)
Canonical SMILESOC1=CC=C(C([2H])([2H])C([2H])([2H])N)C=C1.Cl
分子式C8H7D4NO.HCl
分子量177.7
溶解度DMSO: slightly soluble,Methanol: slightly soluble,Water: slightly soluble
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Tyramine-d4 is intended for use as an internal standard for the quantification of tyramine by GC- or LC-MS. Tyramine is a tyrosine-derived endogenous and dietary monoamine and trace amine-associated receptor 1 (TAAR1) agonist.1,2,3 It activates TAAR1 (EC50s = 0.08, 0.69, and 2.26 μM for rat, mouse, and human-rat chimera receptors, respectively).1 Tyramine also inhibits the release of norepinephrine and dopamine in isolated rat caudate nucleus (IC50s = 40.6 and 119 nM, respectively).4

References
1. Reese, E.A., Bunzow, J.R., Arttamangkul, S., et al. Trace amine-associated receptor 1 displays species-dependent stereoselectivity for isomers of methamphetamine, amphetamine, and para-hydroxyamphetamine. J. Pharmacol. Exp. Ther. 321(1), 178-186 (2007).
2. Zucchi, R., Chiellini, G., Scanlan, T.S., et al. Trace amine-associated receptors and their ligands. Br. J. Pharmacol. 149(8), 967-978 (2006).
3. Maguire, J.J., Parker, W.A.E., Foord, S.M., et al. International Union of Pharmacology. LXXII. Recommendations for trace amine receptor nomenclature. Pharmacol. Rev. 61(1), (2009).
4. Rothman, R.B., Baumann, M.H., Dersch, C.M., et al. Amphetamine-type central nervous system stimulants release norepinephrine more potently than they release dopamine and serotonin. Science 39(1), 32-41 (2001).