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NAD+
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NAD+图片
CAS NO:53-84-9
包装与价格:
包装价格(元)
10mM (in 1mL H2O)电议
1g电议
5g电议

产品介绍

化学性质

StorageStore at -20°C
M.Wt663.43
Cas No.53-84-9
FormulaC21H27N7O14P2
Solubility≥28.55 mg/mL in H2O; insoluble in EtOH; ≥26.05 mg/mL in DMSO
Chemical Name[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] [(2R,3S,4R,5R)-5-(3-carbamoylpyridin-1-ium-1-yl)-3,4-dihydroxyoxolan-2-yl]methyl phosphate
Canonical SMILESO[C@H]([C@@H](CO[P@@](O[P@](OC[C@@H]1[C@@H](O)[C@H](O)[C@H](N2C3=NC=NC(N)=C3N=C2)O1)(O)=O)([O-])=O)O[C@H]4[N+]5=CC=CC(C(N)=O)=C5)[C@H]4O
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

NAD+is a coenzyme composed of ribosylnicotinamide 5'-diphosphate coupled to adenosine 5'-phosphate by pyrophosphate linkage. It is often used as a starting point for inhibitor design, a set of 14 analogs with natural NAD+substrate can weakly inhibit NAD glycohydrolase (NADase) activity of CD38 (2 mM < IC50 < 10 mM)[1].

NAD+, also called nicotinamide adenine dinucleotide, act as a signaling molecule and a cofactor or substrate for enzymatic activities.

NAD+ is an oxidizing agent which accepts electrons from other molecules and reduces to NADH[2]. NAD+also plays important roles in the activity of several enzymes such as poly (ADP) – ribose polymerases and cADP – ribose synthases, it can be used by some sirtuins to participate in protein deacetylation mediation, which produce O-acetyl-ADP-ribose and nicotinamide as well as the deacetylated protein[3].

Oral NAD+ supplementation has been used to combat simple fatigue as well as such mysterious and energy-sapping disorders as chronic fatigue syndrome and fibromyalgia[4].

References:

[1]. Division of Biophysics, et al. NAD Analogs in Aid of Chemical Biology and Medicinal Chemistry. Molecules 2019, 24(22), 4187.

[2]. Houtkooper RH1, Cantó C, Wanders R.J., et al. The secret life of NAD+: An old metabolite controlling new metabolic signaling pathways. Endocr. Rev. 2010, 31(2), 194-223.

[3]. Schwer B, Verdin E. Conserved metabolic regulatory functions of sirtuins. Cell Metab. 2008, 7, 104-112.

[4]. Kussmaul, L. and J. Hirst, The mechanism of superoxide production by NADH: ubiquinone oxidoreductase (complex I) from bovine heart mitochondria. Proc Natl Acad Sci U S A, 2006. 103(20): p. 7607-12.