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Valbenazine
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Valbenazine图片
CAS NO:1025504-45-3
包装与价格:
包装价格(元)
2mg电议
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
Valbenazine (NBI-98854) 是一种囊泡单胺转运蛋白 2 (VMAT2) 抑制剂,Ki 为 110-190 nM。
Cas No.1025504-45-3
别名缬苯那嗪,NBI-98854
Canonical SMILESO=C([C@@H](N)C(C)C)O[C@@H]1C[C@]2([H])C3=CC(OC)=C(OC)C=C3CCN2C[C@H]1CC(C)C
分子式C24H38N2O4
分子量418.57
溶解度DMSO : 50 mg/mL (119.45 mM);Water :< 0.1 mg/mL (insoluble)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Valbenazine is a prodrug of the (+)-α isomer of tetrabenazine for tardive syndrome therapy, and inhibits VMAT2 function.

Valbenazine shows a distinctive improvement in tardive dyskinesia symptoms during the successful Phase II trial[1].

References:
[1]. Müller T, et al. Valbenazine granted breakthrough drug status for treating tardive dyskinesia. Expert Opin Investig Drugs. 2015 Jun;24(6):737-42.