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Camostat Mesilate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Camostat Mesilate图片
CAS NO:59721-29-8
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍

化学性质

Physical AppearanceA solid
StorageStore at -20°C
M.Wt494.52
Cas No.59721-29-8
FormulaC20H22N4O5·CH4O3S
Solubilityinsoluble in EtOH; ≥160.6 mg/mL in DMSO; ≥32.15 mg/mL in H2O
Chemical Name[4-[2-[2-(dimethylamino)-2-oxoethoxy]-2-oxoethyl]phenyl] 4-(diaminomethylideneamino)benzoate;methanesulfonic acid
Canonical SMILESCN(C)C(=O)COC(=O)CC1=CC=C(C=C1)OC(=O)C2=CC=C(C=C2)N=C(N)N.CS(=O)(=O)O
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

Camostat is a trypsin-like protease inhibitor, inhibits airway epithelial sodium channel (ENaC) function with IC50 of 50 nM, less potent to trpsin, prostasin and matriptase.

试验操作

Cell experiment:[1]

Cell lines

Rat primary hepatic stellate cells (HSCs)

Reaction Conditions

500 μmol/L camostat mesilate for 7 d incubation

Applications

Camostat mesilate (500 μmol/L) inhibited generation of transforming growth factor β (TGF-β) by suppressing plasmin activity and reduced the activity of TGF-β, which blockedin vitroactivation of HSCs.

Animal experiment:[1]

Animal models

Male Wistar rats

Dosage form

1 ~ 2 mg/g

Diet

Applications

Camostat mesilate (1 ~ 2 mg/g of diet) markedly attenuated an increase in hepatic plasmin and TGF-β levels, HSC activation, and hepatic fibrosis without apparent systemic or local side effects in porcine serum-treated rats. Therefore, camostat mesilate prevented porcine serum-induced rat hepatic fibrosis via a profound reduction in TGF-β generation

Note

The technical data provided above is for reference only.

References:

1. Okuno M, Akita K, Moriwaki H, et al. Prevention of rat hepatic fibrosis by the protease inhibitor, camostat mesilate, via reduced generation of active TGF-beta. Gastroenterology, 2001, 120(7): 1784-1800.