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M4205
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
M4205图片
CAS NO:2590556-80-0
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍

M4205 (M-4205) is a highly selective inhibitor of disease-relevant cKIT mutations for unresectable metastatic or recurrent gastrointestinal stromal tumors (GIST). It had high activity against exon 11, 13 and 17 mutations of cKIT, with high kinase selectivity, with excellent metabolic stability, permeability, and solubility. Preclinical studies of M4205 in GIST xenograft models expressing mutations in exon 11 showed that M4205 delivered strong responses compared with imatinib. Compared with second-line standard of care sunitinib, M4205 treatment resulted in deeper anti-tumor response in xenograft models expressing secondary resistance mutations in exon 13. Similar results were seen in a xenograft model expressing secondary resistance mutations in exon 17. M4205 has the potential to become a best-in-class option for GIST. There is a phase I clinical study of GIST in preparation.

纯度:≥98%

CAS:2590556-80-0