| CAS NO: | 69-74-9 |
| 包装 | 价格(元) |
| 200mg | 电议 |
| 1g | 电议 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 279.68 |
| Cas No. | 69-74-9 |
| Formula | C9H14ClN3O5 |
| Solubility | insoluble in EtOH; ≥14.2 mg/mL in DMSO; ≥64.2 mg/mL in H2O |
| Chemical Name | 4-amino-1-[(2R,3S,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one;hydrochloride |
| Canonical SMILES | C1=CN(C(=O)N=C1N)C2C(C(C(O2)CO)O)O.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Cytarabine hydrochloride是治疗白血细胞癌的有效药物[1].
Cytarabine hydrochloride是一种脱氧胞苷(dC)类似物.Cytarabine hydrochloride被磷酸化成三磷酸形式,从而与dCTP竞争掺入DNA.据报道,Cytarabine hydrochloride掺入到DNA中,抑制DNA和RNA聚合酶功能,最终阻断DNA合成.在急性骨髓性白血病(AML)细胞生长抑制实验中,Cytarabine hydrochloride掺入呈剂量依赖性地抑制细胞生长,对CCRF-CEM\CEM/AraC8C和CEM/dCK细胞系的IC50值分别为16 nM\103 μM和223 μM.WST-1试验表明,在逆转录病毒传感器大鼠白血病KA细胞中,Cytarabine hydrochloride对KA\KA/GFP和KA/wt的IC50值分别为0.69 μM\1.73 μM和0.037 μM[1,2].
参考文献：
[1] Tobias SC1, Borch RF. Synthesis and biological evaluation of a cytarabine phosphoramidate prodrug. Mol Pharm. 2004 Mar-Apr; 1(2):112-6.
[2] Veuger MJ1, Heemskerk MH, Honders MW, Willemze R, Barge RM. Functional role of alternatively spliced deoxycytidine kinase in sensitivity to cytarabine of acute myeloid leukemic cells. Blood. 2002 Feb 15; 99(4):1373-80.
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