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Streptozocin
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Streptozocin图片
CAS NO:18883-66-4
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
100mg电议
200mg电议
500mg电议

产品介绍

化学性质

Physical AppearanceA solid
StorageStore at -20°C
M.Wt265.22
Cas No.18883-66-4
FormulaC8H15N3O7
Solubility≥10.3 mg/mL in DMSO; ≥26.5 mg/mL in EtOH with gentle warming; ≥53.2 mg/mL in H2O
Chemical Name1-methyl-1-nitroso-3-[2,4,5-trihydroxy-6-(hydroxymethyl)oxan-3-yl]urea
Canonical SMILESO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1NC(N(N=O)C)=O
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Antibiotic and antitumor agent. Alkylates DNA and induces diabetes mellitus via reduction of nicotinamide adenine dinucleotide in pancreatic β-cellsin vivo.

试验操作

Cell experiment:[1]

Cell lines

A murine pancreatic β cell line, INS-1

Reaction Conditions

15 or 30 mM streptozocin for 1 h incubation

Applications

Higher rates of apoptosis, as compared to necrosis, were observed when cells were exposed to 15 mM streptozocin for 1 h followed by a 24 h recovery period. Higher doses of streptozocin (30 mM) caused the cells to undergo necrosis (22%) as well as apoptosis (17%). Streptozotocin at low doses induced apoptosis and at high doses caused necrosis in INS-1 cells.

Animal experiment:[2]

Animal models

Male adult Holtzman rats

Dosage form

50, 65 or 100 mg/kg

A single intravenous injection

Applications

Streptozotocin (65 mg/kg) resulted in rapid degranulation of β cells, accumulation of glycogen in the proximal convoluted tubules of the kidney, as well as development of cataracts in 4 months after streptozotocin treatment. At a higher dose of 100 mg/kg, streptozotocin produced lesions in the exocrine cells of the pancreas, and led to persistence of small, possibly secretory, granules in the Golgi zone of β cells in diabetic rats. Streptozotocin is often used to induce diabetes mellitus in experimental animals.

Note

The technical data provided above is for reference only.

References:

1. Saini KS, Thompson C, Winterford CM, et al. Streptozotocin at low doses induces apoptosis and at high doses causes necrosis in a murine pancreatic beta cell line, INS-1. Biochemistry and Molecular Biology International, 1996, 39(6): 1229-1236.

2. Arison RN, Ciaccio EI, Glitzer MS, et al. Light and electron microscopy of lesions in rats rendered diabetic with streptozotocin. Diabetes, 1967, 16(1): 51-56.