CAS NO: | 2094547-67-6 |
包装 | 价格(元) |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
Cas No. | 2094547-67-6 |
Canonical SMILES | C=CC(N1CCC(C)=C(C2=CC=CO2)C1)=O |
分子式 | C13H15NO2 |
分子量 | 217.26 |
溶解度 | DMSO: 5 mg/mL (23.01 mM); Ethanol: 2 mg/mL (9.21 mM) |
储存条件 | Store at -20°C,unstable in solution, ready to use. |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | EN40 is a potent, selective aldehyde dehydrogenase 3A1 (ALDH3A1) inhibitor as a covalent ligand, exhibits an IC50 value of 2 uM[1] EN40 (10-1000 μM; 48 hours) shows inhibitory effecton ALDH3A1 activity and impairs A549 cell survival[1]. Cell Viability Assay[1] Cell Line: A549 cells EN40 (intraperitoneal injection; 50mg/kg; from 14 days; once per day) exerts strong anti-tumorigenic effects in established A549 tumor xenografts, shows good tolerability with no body weight loss in mice[1]. Animal Model: SCID mice with A549 cells[1] [1]. Counihan JL,et al.Chemoproteomics-Enabled Covalent Ligand Screening Reveals ALDH3A1 as a Lung Cancer Therapy Target.ACS Chem Biol. 2018 Aug 17;13(8):1970-1977 |