| CAS NO: | 5144-89-8 |
| 包装 | 价格(元) |
| 10g | 电议 |
| 25g | 电议 |
| 50g | 电议 |
| 100g | 电议 |
| Cas No. | 5144-89-8 |
| 别名 | 邻菲罗啉,1,10-Phenanthroline monohydrate |
| Canonical SMILES | C12=CC=C3C(N=CC=C3)=C1N=CC=C2.O |
| 分子式 | C12H8N2.H2O |
| 分子量 | 198.2 |
| 溶解度 | DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:9): 0.1 mg/ml,Ethanol: 1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | 1,10-Phenanthrine is a metal chelator and inhibitor of metalloproteases.1,2,3 It inhibits zinc-dependent hydrolysis of Fa-Gly-Leu-NH2 by B. subtilis neutral protease and B. thermoproteolyticus thermolysin.1 1,10-Phenanthrine is fungistatic against P. verrucosa (MIC = 0.8 μg/ml) and inhibits zinc-induced P. verrucosa metallo-type peptidase activity in a concentration-dependent manner.2 It induces uncoupling of and inhibits egg production by adult S. mansoni worm pairs in vitro when used at concentrations ranging from 0.5 to 150 μM.3 1,10-Phenanthrine (20 mg/kg per day) reduces worm burden in a mouse model of S. mansoni infection. |1. Feder, J., Garrett, L.R., and Kochavi, D. Studies on the inhibition of neutral proteases by 1,10-phenanthroline. Biochim. Biophys. Acta 235(2), 370-377 (1971).|2. Granato, M.Q., Massapust, P.d.A., Rozental, S., et al. 1,10-Phenanthroline inhibits the metallopeptidase secreted by Phialophora verrucosa and modulates its growth, morphology and differentiation. Mycopathologia 179(3-4), 231-242 (2014).|3. Day, T.A., and Chen, G.-Z. The metalloprotease inhibitor 1,10-phenanthroline affects Schistosoma mansoni motor activity, egg laying and viability. Parasitology 116(Pt. 4), 319-325 (1998). |
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