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(R)-Trolox
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
(R)-Trolox图片
CAS NO:53101-49-8
包装与价格：
包装价格(元)
Free Sample (0.1-0.5mg)电议
10mM (in 1mL DMSO)电议
50mg电议
100mg电议
200mg电议
500mg电议

产品介绍
(R)-Trolox 是水溶性维生素 E 类似物，是一种竞争性酪氨酸酶抑制剂，Ki 值为 0.83 mM，ID50 值为 1.88 mM。(R)-Trolox 具有比 (S) 对映异构体更强的酪氨酸酶亲和力 (Ki 值为 0.61 mM)。
Cas No.53101-49-8
别名(R)-(+)-6-羟基-2,5,7,8-四甲基色满-2-羧酸
Canonical SMILESO=C([C@@]1(C)CCC2=C(C)C(O)=C(C)C(C)=C2O1)O
分子式C14H18O4
分子量250.29
溶解度DMSO: 250 mg/mL (998.84 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

(R)-Trolox is a water soluble vitamin E analogue and a competitive tyrosinase inhibitor with a Ki value of 0.83 mM and a ID50 value of 1.88 mM[1]. The (R)-Trolox has stronger tyrosinase affinity than the (S) enantiomer (Ki value of 0.61 mM)[1].

As compared to the control containing no inhibitor, DMSO suppresses the tyrosinase activity at tested levels, 100 and 200 µL in a total volume of 3.0 mL. The inhibition of DMSO on the mushroom tyrosinase is dosedependent. Additions of DMSO at the two levels in the tyrosinase digests containing (R)-Trolox ((R)-HTCCA) results in further inhibitions of the tyrosinase activity. The influence of the DMSO on the inhibitory effects of (R)-Trolox against the tyrosinase is also dose-dependent[1].

[1]. Yu L. Inhibitory effects of (S)- and (R)-6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acids on tyrosinase activity. J Agric Food Chem. 2003 Apr 9;51(8):2344-7.