您好,欢迎来到化工原料网! [登录] [免费注册]
化工原料网
位置:首页 > 产品库 > Glabrol
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
Glabrol
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Glabrol图片
CAS NO:59870-65-4
包装与价格:
包装价格(元)
5mg电议
10mg电议

产品介绍
Glabrol (Compound 1) 是从甘草根的乙醇提取物中分离得到的一种异戊二烯类黄酮,是一种有效且非竞争性的 ACAT (酰基辅酶 A:胆固醇酰基转移酶)抑制剂,对大鼠肝脏微粒体 ACAT 的 IC50 值为 24.6 μM。
Cas No.59870-65-4
别名光甘草醇
Canonical SMILESO=C1C[C@@H](C2=CC=C(O)C(C/C=C(C)\C)=C2)OC3=C(C/C=C(C)\C)C(O)=CC=C13
分子式C25H28O4
分子量392.49
溶解度Soluble in DMSO
储存条件4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC50 value of 24.6 μM for rat liver microsomal ACAT activity[1].

Glabrol (Compound 1) decreases cholesteryl ester formation with an IC50 value of 26.0 μM in HepG2 cells[1].

[1]. Choi JH, et al. Glabrol, an acyl-coenzyme A: cholesterol acyltransferase inhibitor from licorice roots. J Ethnopharmacol. 2007 Apr 4;110(3):563-6.