包装 | 价格(元) |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 6415.39 |
Formula | C279H468N80O90S1 |
Synonyms | H2N-Leu-Ala-Pro-Met-Glu-Gly-Ile-Arg-Arg-Pro-Asp-Gln-Ala-Leu-Leu-Pro-Glu-Leu-Pro-Gly-Leu-Gly-Leu-Arg-Ala-Pro-Leu-Lys-Lys-Thr-Thr-Ala-Glu-Gln-Ala-Glu-Glu-Asp-Leu-Leu-Gln-Glu-Ala-Gln-Ala-Leu-Ala-Glu-Val-Leu-Asp-Leu-Gln-Asp-Arg-Glu-Pro-Arg-OH |
Solubility | insoluble in EtOH; insoluble in DMSO; ≥100 mg/mL in H2O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
刺鼠相关蛋白(刺鼠相关肽AgRP)是大脑内AgRP/NPY神经元产生的神经肽。刺鼠相关肽只在下丘脑中弓状核的腹内侧部分含有NPY的细胞体中合成。刺鼠相关蛋白主要在肾上腺、丘脑底核和下丘脑中表达,在睾丸、肾和肺中的表达水平相对较低(1)。AgRP具有刺激食欲的作用,这种作用可以被瘦素抑制,被生长素激活。脂肪细胞响应于食物摄取,分泌瘦素。这种激素作用于弓状核,抑制AgRP / NPY神经元释放开胃肽(2)。NPY / AgRP神经元中含有生长素受体,可以刺激NPY和AgRP的分泌,增进食欲。AgRP存储在细胞内的分泌颗粒中,通过可调节的通路进行分泌。AgRP的转录和分泌作用可由炎症信号调节。在禁食期间,AgRP的表达增加。研究发现,AgRP刺激下丘脑-垂体-肾上腺皮质轴释放促肾上腺皮质激素、皮质醇和催乳素。它还增强促肾上腺皮质激素对IL-1β的应答,表明AgRP可能在神经内分泌对炎症的响应中发挥调节作用(3)。
Figure1 the structures of Agouti-related Protein (AGRP)
Figure2 the Agouti-related Protein (AGRP) pathway
参考文献:
1. Bäckberg M, Madjid N, Ogren SO, Meister B (June 2004). "Down-regulated expression of agouti-related protein (AGRP) mRNA in the hypothalamic arcuate nucleus of hyperphagic and obese tub/tub mice".Brain Res. Mol. Brain Res.125 (1-2): 129–39.
2. Enriori PJ, Evans AE, Sinnayah P, Jobst EE, Tonelli-Lemos L, Billes SK, Glavas MM, Grayson BE, Perello M, Nillni EA, Grove KL, Cowley MA (March 2007). "Diet-induced obesity causes severe but reversible leptin resistance in arcuate melanocortin neurons".Cell Metabolism5 (3): 181–94.
3. Xiao E, Xia-Zhang L, Vulliémoz NR, Ferin M, Wardlaw SL (May 2003). "Agouti-related protein stimulates the hypothalamic-pituitary-adrenal (HPA) axis and enhances the HPA response to interleukin-1 inthe primate".Endocrinology144 (5): 1736–41.