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Lapaquistat
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lapaquistat图片
CAS NO:189059-71-0
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
Lapaquistat (T-91485) 是一种胆固醇生物合成 cholesterol biosynthesis 的抑制剂,是 TAK-475 的活性代谢产物。Lapaquistat 可以降低他汀类药物在降脂治疗中的肌毒性。
Cas No.189059-71-0
别名T-91485
Canonical SMILESO=C(O)CC1CCN(C(C[C@@H]2C(N(CC(C)(C)CO)C3=CC=C(Cl)C=C3[C@@H](C4=CC=CC(OC)=C4OC)O2)=O)=O)CC1
分子式C31H39ClN2O8
分子量603.1
溶解度DMSO: 25 mg/mL (41.45 mM)
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Lapaquistat (T-91485), a cholesterol biosynthesis inhibitor, is the active metabolite of TAK-475. Lapaquistat can decrease statin-induced myotoxicity in lipid-lowering therapy[1].

[1]. Nishimoto T, et al. Comparing myotoxic effects of squalene synthase inhibitor, T-91485, and 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors in human myocytes. Biochem Pharmacol. 2003 Dec 1;66(11):2133-9.