| CAS NO: | 1716-12-7 |
| 包装 | 价格(元) |
| 10mM (in 1mL H2O) | 电议 |
| 100mg | 电议 |
| 200mg | 电议 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 186.18 |
| Cas No. | 1716-12-7 |
| Formula | C10H11O2·Na |
| Solubility | ≥27.65 mg/mL in H2O; ≥50.9 mg/mL in EtOH with ultrasonic; ≥6.3 mg/mL in DMSO |
| Chemical Name | sodium;4-phenylbutanoate |
| Canonical SMILES | C1=CC=C(C=C1)CCCC(=O)[O-].[Na+] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Sodium Phenylbutyrate is a histone deacetylase (HDAC) inhibitor [1].
HDAC, negatively regulating acetylation of histones, plays an important role in acetylation homeostasis which is a major epigenetic mechanism in cancer development and heart dysfunction [1].
In oral squamous cell carcinoma (OSCC) cell lines CAL27, HSC3, and SCC4, a series of doses of Sodium Phenylbutyrate including 1, 2, 4, 8, and 16 mM, inhibited all cell lines in a dose dependent manner, with IC50 values of 4.091, 3.712, and 3.015 mM, respectively. In HSC3 and SCC4 cells treated with 4 or 3 mM Sodium Phenylbutyrate for 12, 48, and 72 h, significant inhibition on cell vitality could be observed in a time dependent manner [2].
In a mouse model with Adriamycin-induced cardiac injury, Sodium Phenylbutyrate (400 mg/kg/day) was i.p. injected one day before and daily after the Adriamycin injection for two days. Sodium Phenylbutyrate substantially reversed the Adriamycin-induced elevation of creatine kinase and serum lactase dehydrogenase activities, and meanwhile, diminished Adriamycin-induced ultrastructual damages of cardiac tissue by more than 70%. In addition, Sodium Phenylbutyrate completely rescued Adriamycin-associated reduction of cardiac functions, and increased cardiac manganese superoxide dismutase (MnSOD) protein and activity [1].
References:
[1]. Daosukho C, Chen Y, Noel T, et al. Phenylbutyrate, a histone deacetylase inhibitor, protects against Adriamycin-induced cardiac injury. Free Radical Biology and Medicine, 2007, 42(12): 1818-1825.
[2]. Qian K, Sun L, Zhou G, et al. Sodium Phenylbutyrate Inhibits Tumor Growth and the Epithelial-Mesenchymal Transition of Oral Squamous Cell Carcinoma In Vitro and In Vivo. Cancer Biotherapy and Radiopharmaceuticals, 2018, 33(4): 139-145.
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