| CAS NO: | 106392-48-7 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| Storage | Store at -20°C |
| M.Wt | 272.34 |
| Cas No. | 106392-48-7 |
| Formula | C16H20N2O2 |
| Solubility | ≥25.9 mg/mL in DMSO |
| Chemical Name | (E)-2-cyano-3-(4-hydroxy-3,5-diisopropylphenyl)acrylamide |
| Canonical SMILES | O=C(/C(C#N)=C/C1=CC(C(C)C)=C(O)C(C(C)C)=C1)N |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
ST271是蛋白酪氨酸激酶（PTK）的有效抑制剂，抑制由fMet-Leu-Phe和PAF刺激的磷脂酶D的激活，IC50s分别为6.7和9μM[1]。ST271在膜制备和通透性血小板中部分抑制肽的磷酸化[2]。ST271（100μM）完全抑制FcγRII交联诱导的肌醇磷酸酯的形成，但也诱发了对凝血酶和U46619小幅度（<30%）却显著的响应抑制[3]。
参考文献：
[1]. Uings IJ, Thompson NT, Randall RW, Spacey GD, Bonser RW, Hudson AT, Garland LG. Tyrosine phosphorylation is involved in receptor coupling to phospholipase D but not phospholipase C in the human neutrophil. Biochem J. 1992 Feb 1;281 (Pt3) (Pt 3):597-600. doi: 10.1042/bj2810597. Erratum in: Biochem J 1992 May 1;283(Pt 3):919. PMID: 1371383; PMCID: PMC1130730.
[2]. Martinson EA, Scheible S, Presek P. Inhibition of phospholipase D of human platelets by protein tyrosine kinase inhibitors. Cell Mol Biol (Noisy-le-grand). 1994 Jul;40(5):627-34. PMID: 7526916.
[3]. Blake RA, Asselin J, Walker T, Watson SP. Fc gamma receptor II stimulated formation of inositol phosphates in human platelets is blocked by tyrosine kinase inhibitors and associated with tyrosine phosphorylation of the receptor. FEBS Lett. 1994 Mar 28;342(1):15-8. doi: 10.1016/0014-5793(94)80575-x. PMID: 8143842.
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