| 包装 | 价格(元) |
| 10ug | 电议 |
| 50ug | 电议 |
| 别称 | C87615 Protein, Mouse; Csfm Protein, Mouse; MCSF Protein, Mouse; op Protein, Mouse. |
| Gene ID | 12977 |
| Accession # | P07141-1 |
| 蛋白序列 | Met1-Glu262 |
| 分子量 | 26 kDa |
| 来源 | 293T cells |
| 生物活性 | 以下数据来自于小鼠CTLL-2细胞的剂量依赖性实验： ED50：< 0.1 ng/mL 放射性比度：>1x107units/mg. |
| 产品形式 | 该蛋白以溶解于PBS缓冲液的形式提供。 |
| 存储说明 | 此产品可稳定存在于如下条件中： 4°C保存一周； -20°C保存3个月。 请避免多次反复冻融。 |
Macrophage colony-stimulating factor 1, also known as CSF-1, M-CSF, Lanimostim and CSF1, is a single-pass membrane protein which is disulfide-linked as a homodimer or heterodimer. Granulocyte / macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. M-CSF/CSF-1 is known to facilitate monocyte survival, monocyte-to-macrophage conversion, and macrophage proliferation. M-CSF/CSF-1 is a secreted cytokine which influences hemopoietic stem cells to differentiate into macrophages or other related cell types. It binds to the Colony stimulating factor 1 receptor. M- CSF/CSF-1 may also be involved in development of the placenta. The active form of M-CSF/CSF-1 is found extracellularly as a disulfide-linked homodimer, and is thought to be produced by proteolytic cleavage of membrane-bound precursors. M-CSF/CSF-1 induces cells of the monocyte/macrophage lineage. It also plays a role in immunological defenses, bone metabolism, lipoproteins clearance, fertility and pregnancy. Upregulation of M-CSF/CSF-1 in the infarcted myocardium may have an active role in healing not only through its effects on cells of monocyte/macrophage lineage, but also by regulating endothelial cell chemokine expression.
参考文献：
1. Pandit J, Bohm A, Jancarik J, Halenbeck R, Koths K, Kim SH. Three-dimensional structure of dimeric human recombinant macrophage colony-stimulating factor. Science. 1992 Nov 20;258(5086):1358-62. doi: 10.1126/science.1455231. PMID: 1455231.
2. Tokai M, Kawasaki H, Kikuchi Y, Ouchi K. Cloning and characterization of the CSF1 gene of Saccharomyces cerevisiae, which is required for nutrient uptake at low temperature. J Bacteriol. 2000 May;182(10):2865-8. doi: 10.1128/jb.182.10.2865-2868.2000. PMID: 10781556; PMCID: PMC101996.
3. Fan X, Fan D, Gewant H, Royce CL, Nanes MS, Rubin J. Increasing membrane-bound MCSF does not enhance OPGL-driven osteoclastogenesis from marrow cells. Am J Physiol Endocrinol Metab. 2001 Jan;280(1):E103-11. doi: 10.1152/ajpendo.2001.280.1.E103. PMID: 11120664.
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