| 包装 | 价格(元) |
| 10ug | 电议 |
| 50ug | 电议 |
| 别称 | DFNB39 Protein, Human; F-TCF Protein, Human; F-TCFB Protein, Human; Hepatocyte Growth Factor Protein, Human; HGFB Protein, Human; HPTA Protein, Human; SF Protein, Human. |
| Accession # | P14210-1 |
| 蛋白序列 | Met 1-Ser 728 |
| 分子量 | 79.7 kDa |
| 来源 | 293T细胞 |
| 生物活性 | 以下数据来自于小鼠CTLL-2细胞的剂量依赖性实验： ED50：< 0.1 ng/mL 放射性比度：>1x107units/mg. |
| 产品形式 | 该蛋白以溶解于PBS缓冲液的形式提供。 |
| 存储说明 | 此产品可稳定存在于如下条件中： 4°C保存一周； -20°C保存3个月。 请避免多次反复冻融。 |
Hepatocyte growth factor, also known as HGF, contains 4 kringle domains, 1 PAN domain and 1 peptidase S1 domain. It belongs to the peptidase S1 family, plasminogen subfamily. Hepatocyte growth factor is secreted by mesenchymal cellsas a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta- chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor, and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. HGF is a potent mitogen for mature parenchymal hepatocyte cells, seems to be an hepatotrophic factor, and acts as growth factor for a broad spectrum of tissues and cell types. HGF has no detectable protease activity. Defects in hepatocyte growth factor are the cause of deafness autosomal recessive type 39. A form of profound prelingual sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
参考文献：
1. Naldini L, Weidner KM, Vigna E, Gaudino G, Bardelli A, Ponzetto C, Narsimhan RP, Hartmann G, Zarnegar R, Michalopoulos GK, et al. Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor. EMBO J. 1991 Oct;10(10):2867-78. PMID: 1655405; PMCID: PMC452997.
2. Comoglio PM. Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells. EXS. 1993;65:131-65. PMID: 8380735.
3. Hahn W, Pyun WB, Kim DS, Yoo WS, Lee SD, Won JH, Shin GJ, Kim JM, Kim S. Enhanced cardioprotective effects by coexpression of two isoforms of hepatocyte growth factor from naked plasmid DNA in a rat ischemic heart disease model. J Gene Med. 2011 Oct;13(10):549-55. doi: 10.1002/jgm.1603. PMID: 21898720.
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