| 包装 | 价格(元) |
| 10ug | 电议 |
| 50ug | 电议 |
| 别称 | IGF1A, Insulin-Like Growth Factor 1, Somatomedin C, IGF-I, IGFI, IGF1, IGF-IA, Mechano growth factor, MGF. | Gene ID | 3479 | Accession # | P05019 |
| 蛋白序列 | Gly49-Ala118 |
| 分子量 | 7.6 kDa |
| 来源 | 293T细胞 |
| 生物活性 | 以下数据来自于小鼠CTLL-2细胞的剂量依赖性实验： ED50：< 0.1 ng/mL 放射性比度：>1x107units/mg. |
| 产品形式 | 该蛋白以溶解于PBS缓冲液的形式提供。 |
| 存储说明 | 此产品可稳定存在于如下条件中： 4°C保存一周； -20°C保存3个月。 请避免多次反复冻融。 |
Insulin-like growth factor I (IGF-1) is a polypeptide endocrine hormone structurally similar to insulin and is mainly produced in the liver when stimulated by growth hormone. IGF-1 is a growth factor that stimulates the proliferation of various cell types including muscle, bone, and cartilage tissue. IGF-1 binds and interacts with the IGF-1 binding proteins (IGFBPs). IGF-1 binds to the IGF-1 receptor with a higher affinity than the insulin receptor.
Human IGF-I is synthesized as two precursor isoforms with N- and alternate C-terminal propeptides, which are proteolyzed to produce the identical 7.6 kDa mature IGF-I. Mature human IGF I shares 94% and 96% aa sequence identity with mouse IGF1 and rat IGF1, respectively, and exhibits cross species activity. Human IGF-1 is a 7.6 kDa protein containing 70 amino acid residues. The recombinant human IGF-1 was produced using animal origin free technology.
参考文献：
1. Zhao Y, Wang Q, et al. "Glutamine protects against oxidative stress injury through inhibiting the activation of PI3K/Akt signaling pathway in parkinsonian cell model." Environ Health Prev Med. 2019 Jan 5;24(1):4.
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