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Succinyl-Coenzyme A(sodium salt)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Succinyl-Coenzyme A(sodium salt)图片
CAS NO:108347-97-3
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍
琥珀酰辅酶 A (Succinyl-CoA) 钠是柠檬酸循环的中间体。
Cas No.108347-97-3
别名琥珀酰辅酶A钠盐,Succinyl-CoA
化学名S-(hydrogen butanedioate), coenzyme A, sodium salt
Canonical SMILESO[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(CCC(O)=O)=O)=O)=O)(O)=O)(O)=O)[C@H]1OP(O)(O)=O.[Na]
分子式C25H40N7O19P3S•XNa
分子量867.6
溶解度10mg/mL in PBS, pH 7.2
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Succinyl-coenzyme A (succinyl-CoA) is an intermediate in the citric acid cycle.[1] It is converted to succinate, which is a metabolic intermediate with various biological activities. Succinyl-CoA is required, with glycine, to form δ-aminolevulinic acid in the first step of porphyrin and heme synthesis.[2] Succinyl-CoA deficiency, caused by vitamin B12 deficiency can disrupt heme and energy production, leading to neuromotor dysfunction.[3]

Reference:
[1]. Meister, A. ACYL phosphates as enzyme-bound intermediates in the biosynthesis of glutamine, glutathione, succinyl, coenzyme A, and cabamyl phosphate. Trans. N. Y. Acad. Sci. 30(8), 1157-1180 (1968).
[2]. Bonkovsky, H.L., Guo, J.-T., Hou, W., et al. Porphyrin and heme metabolism and the porphyrias. Compr Physiol 3(1), 365-401 (2013).
[3]. Bicakci, Z. Growth retardation, general hypotonia, and loss of acquired neuromotor skills in the infants of mothers with cobalamin deficiency and the possible role of succinyl-CoA and glycine in the pathogenesis. Medicine (Baltimore) 94(9), e584 (2015).