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MK-0941
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
MK-0941图片
CAS NO:1137916-97-2
包装与价格:
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
MK-0941 是一种有效的、具有口服活性的变构葡萄糖激酶激活剂,在 2.5 和 10 mM 葡萄糖存在下,重组人葡萄糖激酶的 EC50 分别为 240 和 65 nM。
Cas No.1137916-97-2
Canonical SMILESCCS(C1=CC=C(OC2=CC(O[C@@H](C)CO)=CC(C(NC3=NN(C)C=C3)=O)=C2)C=N1)(=O)=O.O=S(O)(C)=O
分子式C21H24N4O6S•CH3SO3H
分子量556.6
溶解度DMF: 20 mg/ml,DMSO: 20 mg/ml,Ethanol: 5 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MK-0941 is a glucokinase activator with EC50 values of 0.24 and 0.065 µM at low (2.5 mM) and high (10 mM) concentrations of glucose, respectively. It increases insulin secretion from isolated rat islets of Langerhans and glucose uptake by hepatocytes in vitro. MK-0941 reduces blood glucose levels in high-fat diet-fed db/db mice and in high-fat diet-fed mice with diabetes induced by streptozotocin .