化学性质
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 614.6 |
| Cas No. | 681281-88-9 |
| Formula | C31H27N4S·I |
| Solubility | ≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide |
| Canonical SMILES | CC[N+]1=C(/C=C/N(C2=CC=CC=C2)C)N(C3=CC=CC=C3)C4=CC=C(C5=NC(C=CC=C6)=C6S5)C=C41.[I-] |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
资料参考
Akt inhibitor IV is an inhibitor of Akt activation that inhibits Akt-mediated nuclear export of Forkhead box class O transcription factor 1a (FOXO1a; IC50= 625 nM) and reduces phosphorylation of Akt at Ser473and Thr308in a dose-dependent manner.1Akt inhibitor IV inhibits replication of parainfluenza virus 5 (PIV5) in HeLa cells (IC50= 520 nM).2It also reduces the growth of cancer cells (IC50= 0.3 μM for both Jurkat and HeLa cells) via a reduction in mitochondrial polarization and increased production of reactive oxygen species (ROS).3
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