化学性质
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 227.22 |
| Cas No. | 951-77-9 |
| Formula | C9H13N3O4+adduct |
| Solubility | ≥22.7 mg/mL in DMSO; insoluble in EtOH; ≥48 mg/mL in H2O |
| Chemical Name | 1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-4-imino-1,4-dihydropyrimidin-2-ol |
| Canonical SMILES | N=C1C=CN(C(O)=N1)[C@@]2([H])C[C@@](O)([H])[C@@](O2)([H])CO |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
资料参考
2-Deoxycytidine is a cytidine analog.
2-Deoxycytidine prevents DNA methylation by incorporating itself into newly synthesizing DNA strand. 2-Deoxycytidine also binds to DNA methyltransferase irreversibly and hinders its activity. Thus, 2-deoxycytidine was approved as the most efective demethylating agent for the treatment of cancer .
2-Deoxycytidine at clinically achievable and nontoxic concentrations (≥ 100 μmol/L) protected normal bone marrow progenitor cells against the inhibitory effects of co-administered, high concentrations of 3’-azido-3’-deoxythymidine (AZT) (≥ 10 μmol/L). In normal bone marrow mononuclear cells (BMMC), 2-deoxycytidine also significantly corrected AZT-mediated depletion of intracellular thymidine triphosphate and 2-deoxycytidine triphosphate levels. Furthermore, 2-deoxycytidine reduced the intracellular accumulation of AZT triphosphate and its DNA incorporation in BMMC .
In a rat model of myocardial infarction induced by ligating left anterior descending coronary artery, human umbilical cord mesenchymal stem cells treated with 2-deoxycytidine(5, 10, 20 and 40 μM) before transplantation to the left ventricular wall immediately after ligation significantly improved the cardiac systolic and diastolic functions, and pumping ability. Fibrotic area and left ventricular wall thickness were also significantly improved .
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