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1H-1-ethyl Candesartan Cilexetil
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
1H-1-ethyl Candesartan Cilexetil图片
CAS NO:914613-35-7
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议

产品介绍

化学性质

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt638.7
Cas No.914613-35-7
FormulaC35H38N6O6
Solubility≤30mg/ml in DMSO;30mg/ml in dimethyl formamide
Chemical Name2-ethoxy-1-[[2'-(1-ethyl-1H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-1H-benzimidazole-7-carboxylic acid, 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester
Canonical SMILESO=C(OC(C)OC(C1=C(N(CC2=CC=C(C3=C(C4=NN=NN4CC)C=CC=C3)C=C2)C(OCC)=N5)C5=CC=C1)=O)OC6CCCCC6
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

1H-1-ethyl Candesartan Cilexetil, which is a process-related impurity commonly found in the bulk synthesis of candesartan cilexetil, is a potent, long-acting, and selective angiotensin II type 1 receptor (AT1) antagonist.

Angiotensin II is a peptide that is mainly generated by the angiotensin converting enzyme and chymase, which plays a vital role in regulating blood pressure and sodium homeostasis via specific receptors including AT1[1]. AT1, localized in the kidney, heart, brain, adrenal gland, adipocytes, vascular smooth muscle cells, platelets, and placenta, is a major component of the renin-angiotensin system. Furthermore, AT1 mediates the classical biological actions of angiotensin II. Also, AT1 has seven helical transmembrane domains, which is the characteristic of the superfamily of G-protein-coupled receptors. Carboxyl-terminal region structure of AT1 plays important roles in receptor internalization, desensitization and phosphorylation [2].

In vitro: Up to now, in vitro study of 1H-1-ethyl candesartan cilexetil is still in the development stage.

In vivo: Up to now, in vivo study of 1H-1-ethyl candesartan cilexetil is still in the development stage.

References:
[1].  Otsuka, M. Reduction of bleomycin induced lung fibrosis by candesartan cilexetil, an angiotensin II type 1 receptor antagonist. Thorax. 2004; 59(1): 31-38.
[2].  GUO, D., SUN, Y., HAMET, P., & INAGAMI, T. The angiotensin II type 1 receptor and receptor-associated proteins. Cell Research. 2001; 11(3): 165-180.