| CAS NO: | 6090-95-5 |
| 包装 | 价格(元) |
| 25mg | 电议 |
| 50mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 162.1 |
| Cas No. | 6090-95-5 |
| Formula | C6H10O5 |
| Synonyms | CBE |
| Solubility | ≥18.2 mg/mL in DMSO; ≥1.39 mg/mL in EtOH with ultrasonic; ≥12.6 mg/mL in H2O |
| Chemical Name | 1,2-anhydro-myo-inositol |
| Canonical SMILES | O[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@H]2[C@@H]1O2 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
IC50: 9 μM
Conduritol B epoxide is a β-glucosidase inhibitor.
β-glucosidase catalyzes the hydrolysis of the glycosidic bond to terminal non-reducing residues in β-D-glucosides and oligosaccharides, with release of glucose.
In vitro: Conduritol B epoxide was identifies as an active-site-directed inhibitor of some glucosidases. The inactivation of α-glucosidase from Monascus ruber by conduritol B epoxide was found to be irreversible and first-order with respect to time and inhibitor concentration. The inactivation could be prevented in the presence of maltose [1].
In vivo: The time course of the distribution of [3H]conduritol B epoxide was determined in various organs of mice, which had received a single i.p. dose. Results showd that the epoxide was rapidly distributed over all tissues except brain, indicating that the epoxide could pass the blood/brain barrier only with difficulty. A 4-fold enrichment was observed in the kidney. [3H]conduritol B epoxide was excreted with a half-life of about 7 h. A parallel determination of beta-glucosidase activity in the tissues showed greater than 90% inhibition within 1 and 2 h and a beginning recovery between 4 and 12 h. The only exception was brain, where no effects could be found after 1 h and a subsequent decrease to 37% of normal was seen after 12 h [2].
Clinical trial: So far, no clinical study has been conducted.
References:
[1] Yang SJ, Ge SG, Zeng YC, Zhang SZ. Inactivation of alpha-glucosidase by the active-site-directed inhibitor, conduritol B epoxide. Biochim Biophys Acta. 1985 Apr 29;828(3):236-40.
[2] Stephens MC, Bernatsky A, Singh H, Kanfer JN, Legler G. Distribution of conduritol B epoxide in the animal model for Gaucher's disease (Gaucher mouse). Biochim Biophys Acta. 1981 Jan 7;672(1):29-32.
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