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Dimethyl DL-Glutamate(hydrochloride)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dimethyl DL-Glutamate(hydrochloride)图片
CAS NO:13515-99-6
包装与价格:
包装价格(元)
5g电议
10g电议
25g电议
50g电议

产品介绍

化学性质

Physical AppearanceA crystalline solid
StorageStore at -20°C
M.Wt211.6
Cas No.13515-99-6
FormulaC7H13NO4·HCl
SynonymsGlutamic Acid dimethyl ester,Dimethyl 2-aminopentanedioate
Solubility≤5mg/ml in ethanol;10mg/ml in DMSO;15mg/ml in dimethyl formamide
Chemical Name1,5-dimethyl ester glutamic acid, monohydrochloride
Canonical SMILESCOC(C(N)CCC(OC)=O)=O.Cl
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

Dimethyl DL-glutamate is a cell-permeable form of glutamate.

Extracellular glutamic acid is an excitatory neurotransmitter, while intracellular glutamic acid is an amino acid that serves various metabolic roles.

In vitro: Dimethyl DL-glutamate at 3.0-10.0 mM could enhance insulin release evoked by 6.0-8.3 mM D-glucose, 1.0-10.0 mM L-leucine, or 5.0-10.0 mM 2-amino-bicyclo(2,2,1)heptane-2-carboxylic acid, resulting in a shift to the left of the sigmoidal relationship between insulin output and D-glucose concentration. Moreover, dimethyl DL-glutamate unmasked the insulinotropic potential of glibenclamide in the absence of D-glucose. In islets exposed to L-leucine, the insulinotropic action of dimethyl DL-glutamate coincided with an early fall and later increase in 86Rb outflow. In addition, the overall gain in O2 uptake represented the balance between dimethyl DL-glutamate oxidation and its sparing action on the catabolism of endogenous fatty acids and exogenous D-glucose [1].

In vivo: Dimethyl DL-glutamate was intravenously administered as a primed constant infusion to adult rats that had been injected with streptozotocin during the neonatal period. Results showed that dimethyl DL-glutamate augmented plasma insulin concentration and potentiated and/or prolonged the insulinotropic action of GLP-1 injected intravenously at min 5 of the test [2].

Clinical trial: So far, no clinical study has been conducted.

References:
[1] Sener, A. ,Conget, I.,Rasschaert, J., et al. Insulinotropic action of glutamic acid dimethyl ester. American Journal of Physiology 267(4 Pt 1), E573-E584 (1994).
[2] Cancelas, J. ,Villaneuva-Peacarrillo, M.L.,Valverde, I., et al. Potentiation and prolongation of the insulinotropic action of glucagon-like peptide 1 by methyl pyruvate or dimethyl ester of L-glutamic acid in a type 2 diabetes animal model. Endocrine 16(2), 113-116 (2001).