| CAS NO: | 906366-79-8 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 25mg | 电议 |
| Physical Appearance | A crystalline solid |
| Storage | Store at -20°C |
| M.Wt | 218.2 |
| Cas No. | 906366-79-8 |
| Formula | C12H10O4 |
| Solubility | ≤1mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide |
| Chemical Name | (2Z)-2-[(3,4-dihydroxyphenyl)methylene]-5-methyl-3(2H)-furanone |
| Canonical SMILES | OC1=CC=C(/C=C2OC(C)=CC\2=O)C=C1O |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
IC50: 0.03 and 0.36 μM for COX-2 and COX-1, respectively
Inotilone is a cyclooxygenase (COX) inhibitor.
Many of nonsteroidal anti-inflammatory drugs (NSAIDs) target cyclooxygenases (COX), which catalyze the first two steps in the biosynthesis of the prostaglandins from the substrate arachidonic acid.
In vitro: Inotilone was tested as the inhibitor of mitogen-activated protein kinase, nuclear factor-κB (NF-κB), and matrix-metalloproteinase (MMP)-9 protein expressions in LPS-stimulated RAW264.7 cells. When RAW264.7 macrophages were treated with inotilone with LPS, a significant concentration-dependent inhibition of NO production was detected. It was also found that inotilone could block the protein expression of iNOS, NF-κB, and MMP-9 in LPS-stimulated RAW264.7 macrophages [1].
In vivo: In in vivo tests, inotilone decreased the paw edema after Carr administration, and it increased the activities of catalase (CAT), superoxide dismutase (SOD), and glutathione peroxidase (GPx). Inotilone also significantly attenuated the malondialdehyde (MDA) level in the edema paw. Inotilone decreased the NO and tumor necrosis factor (TNF-α) levels on serum after Carr injection. In addition, an intraperitoneal injection treatment with inotilone could diminish neutrophil infiltration into sites of inflammation, as did indomethacin [1].
Clinical trial: So far, no clinical study has been conducted.
Reference:
[1] Huang GJ, Huang SS, Deng JS. Anti-inflammatory activities of inotilone from Phellinus linteus through the inhibition of MMP-9, NF-κB, and MAPK activation in vitro and in vivo. PLoS One. 2012;7(5):e35922.
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