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DL-α-Difluoromethylornithine(hydrochloride hydrate)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DL-α-Difluoromethylornithine(hydrochloride hydrate)图片
CAS NO:96020-91-6
包装与价格:
包装价格(元)
10mM (in 1mL H2O)电议
50mg电议
100mg电议
500mg电议

产品介绍

化学性质

StorageStore at -20°C
M.Wt236.6
Cas No.96020-91-6
FormulaC6H12F2N2O2·HCl [H2O]
SynonymsDFMO,Eflornithine
Solubilityinsoluble in DMSO; insoluble in EtOH; ≥11.55 mg/mL in H2O
Chemical Name2-(difluoromethyl)-ornithine, monohydrochloride, monohydrate
Canonical SMILESFC(F)C(C(O)=O)(N)CCCN.Cl.O
运输条件蓝冰运输或根据您的需求运输。
一般建议为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。

资料参考

DL-α-Difluoromethylornithine (DFMO) is an irreversible inhibitor of ornithine decarboxylase.

Ornithine decarboxylase catalyzes the decarboxylation of ornithine to form putrescine, which is the committed step in polyamine synthesis.

DFMO inhibited the polyamine synthesis process and displayed antiangiogenic and cytostatic effects in many human tumor cells. In rat bladder carcinoma cell line-804G cells, DFMO inhibited the growth of 804G cells stimulated by Fraction I or by 10% FCS [2].

In female SENCAR mice with skin tumorigenesis model, both oral intake of DFMO (1.5-2.0% wt/vol) and intraperitoneal injection of DFMO (20mg,i.p. and 5mg,i.p.) reduced the sizes and numbers of skin tumor compared to control group [3].

References:
1.  H. M. Wallace, A. V. Fraser and A. Hughes. A perspective of polyamine metabolism. Biochemistry Journal 376(Pt 1), 1-14 (2003).
2.  Homma Y, Ozono S, Numata I, Seidenfeld J,et al. Alpha-Difluoromethylornithine inhibits cell growth stimulated by a tumor-promoting rat urinary fraction. Carcinogenesis. 1985 Jan;6(1):159-61.
3.  Weeks CE, Herrmann AL, Nelson FR, Slaga TJ. Alpha-Difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits tumor promoter-induced polyamine accumulation and carcinogenesis in mouse skin. Proc Natl Acad Sci U S A. 1982 Oct; 79(19):6028-32.