Erythromycin A enol ether

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CAS NO:

33396-29-1

包装与价格：

包装	价格(元)
5mg	电议
10mg	电议

产品介绍

化学性质

Physical Appearance	A crystalline solid
Storage	Store at -20°C
M.Wt	715.9
Cas No.	33396-29-1
Formula	C₃₇H₆₅NO₁₂
Synonyms	BRL 46357ER,EM-201
Solubility	≤30mg/ml in DMSO;15mg/ml in dimethyl formamide
Chemical Name	8,9-didehydro-9-deoxo-6-deoxy-6,9-epoxy-erythromycin
Canonical SMILES	O=C1[C@@H]([C@H]([C@@H]([C@]([H])([C@]2(CC(C)=C([C@@H]([C@H]([C@@](C)([C@H](O1)CC)O)O)C)O2)C)O[C@]3([C@@H]([C@H](C[C@H](O3)C)N(C)C)O)[H])C)O[C@@]4(O[C@H]([C@@H]([C@@](C)(C4)OC)O)C)[H])C
运输条件	蓝冰运输或根据您的需求运输。
一般建议	为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。

资料参考

Erythromycin A enol ether, also known as 8,9-anhydroerythromycin A 6,9 hemiketal, is a kind of catabolite of erythromycin A without its antibiotic properties.

Erythromycin A enol ether functions as a β-turn mimic of the peptide hormone motilin which leads to duodenal contractions. Erythromycin A enol ether is also the agent of gastrointestinal (GI) distress [1].

Motilin is a kind of polypeptide hormone with 22-amino acid belonging to the motilin family. Motilin could increase the migrating myoelectric complex of gastrointestinal motility, and stimulate the pepsin production. Motilin could also improve peristalsis in the small intestine and empty the gut for the next meal. Besides, motilin could facilitate the release of somatostatin and pancreatic polypeptide.

In Vitro: No data available.

In Vivo: No data available.

Clinical trial: No data available.

Reference:
[1] Steinmetz W E, Shapiro B L, Roberts J J, et al. The structure of erythromycin enol ether as a model for its activity as a motilide.[J]. Journal of Medicinal Chemistry, 2002, 45(22): 4899-4902.