| CAS NO: | 737-86-0 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 50mg | 电议 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 286.29 |
| Cas No. | 737-86-0 |
| Formula | C14H14N4O3 |
| Solubility | ≥28.6 mg/mL in DMSO; insoluble in H2O; insoluble in EtOH |
| Chemical Name | (E)-N'-((3-hydroxy-5-(hydroxymethyl)-2-methylpyridin-4-yl)methylene)isonicotinohydrazide |
| Canonical SMILES | CC1=C(O)C(/C([H])=N/NC(C2=CC=NC=C2)=O)=C(CO)C=N1 |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Pyridoxal isonicotinoyl hydrazine是一种细胞通透性的和相对无毒的铁（Fe3 +）螯合剂[1]。
Pyridoxal isonicotinoyl hydrazone (PIH)是一种三齿铁螯合剂，具有高的Fe螯合效力。在59Fe标记的网织红细胞中，PIH (0.1 mmol/L)释放38.6%的胞内59Fe[1]。PIH以剂量依赖的方式抑制抗坏血酸自由基的形成和Fe(III)–EDTA介导的抗坏血酸氧化[3]。
在载Fe大鼠中，PIH口服给药导致粪便铁排泄8倍的增加，可能还会有些尿排泄的铁[1]。在载有铁-乙酰氧肟酸复合物的小鼠中，pyridoxal isonicotinoyl hydrazone口服给药4天，每天300 mg/kg，4天中总的铁排出是31微克/小鼠[2]。Pyridoxal isonicotinoyl hydrazine可用于铁过载疾病中实验性的螯合治疗[3]。
参考文献：
Richardson DR, Ponka P. Pyridoxal isonicotinoyl hydrazone and its analogs: potential orally effective iron-chelating agents for the treatment of iron overload disease. J Lab Clin Med. 1998 Apr;131(4):306-15.
Gale GR, Litchenberg WH, Smith AB, et al. Comparative iron mobilizing actions of deferoxamine, 1,2-dimethyl-3-hydroxypyrid-4-one, and pyridoxal isonicotinoyl hydrazone in iron hydroxamate-loaded mice. Res Commun Chem Pathol Pharmacol. 1991 Sep;73(3):299-313.
Maurício AQ, Lopes GK, Gomes CS, et al. Pyridoxal isonicotinoyl hydrazone inhibits iron-induced ascorbate oxidation and ascorbyl radical formation. Biochim Biophys Acta. 2003 Mar 17;1620(1-3):15-24.
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