| CAS NO: | 1000578-26-6 |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 50mg | 电议 |
| Physical Appearance | Yellow oil |
| Storage | Desiccate at -20°C |
| M.Wt | 283.41 |
| Cas No. | 1000578-26-6 |
| Formula | C18H25N3 |
| Solubility | <28.34mg/ml in ethanol;<28.34mg/ml in DMSO |
| Chemical Name | (2S)-N,N-dimethyl-8-(1,3,5-trimethyl-1H-pyrazol-4-yl)-1,2,3,4-tetrahydronaphthalen-2-amine |
| Canonical SMILES | CC1=NN(C(C)=C1C2=CC=CC3=C2C[C@](N(C)C)([H])CC3)C |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
5-HT7受体在调节睡眠和昼夜节律中发挥作用.此受体通过中枢和外周机制,也在其他CNS疾病中发挥一定的作用,包括认知障碍\焦虑和偏头痛[2].
通过5-HT7受体传递信号,5-羟色胺为增强T细胞活化提供辅助信号.相比于盐处理的对照,PCPA处理的小鼠中T细胞增殖受到显著抑制.PCPA的抑制效应约为18%-49%.加入1 μM 外源性5-HT能够完全恢复T细胞增殖.类似于外源性5-HT,加入1 μM AS 19也能于48小时后完全恢复T细胞增殖能力[4].
SB-258719是选择性的5-HT7受体拮抗剂.10 mg/kg的AS-19与同剂量的SB-258719协同处理(对其本身无效应),在热板和甩尾实验中,AS-19的抗痛觉过敏效应皆被逆转.表明AS-19通过5-HT7受体发挥抗痛觉过敏效应[3].SB269970也是选择性5-HT7受体拮抗剂.一些大鼠通过第二鞘内导管用7 μl 5 mM的SB269970预处理,在所有时间节点,AS-19诱导的PMF被SB269970的预处理所废除,表明AS-19通过5-HT7受体的活化而产生PMF[5].
参考文献：
[1]. Perez-García GS and Meneses A. Effects of the potential 5-HT7 receptor agonist AS 19 in an autoshaping learning task. Behav Brain Res, 2005, 163(1):136-40.
[2]. Thomas DR and Hagan JJ. 5-HT7 Receptors. Current Drug Targets-CNS & Neurological Disorders, 2004, 3(1): 81-90.
[3]. Ulugol A, Oltulu C, Gunduz O, et al. 5-HT7 receptor activation attenuates thermal hyperalgesia in streptozocin-induced diabetic mice. Pharmacol Biochem Behav, 2012, 102(2):344-8.
[4]. León-Ponte M, Ahern GP and O'Connell PJ. Serotonin provides an accessory signal to enhance T-cell activation by signaling through the 5-HT7 receptor. Blood, 2007, 109(8):3139-46.
[5]. Hoffman MS and Mitchell GS. Spinal 5-HT7 receptor activation induces long-lasting phrenic motor facilitation. J Physiol, 2011, 589(Pt 6):1397-407.
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