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Pentagastrin(ICI-50123)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Pentagastrin(ICI-50123)图片
CAS NO:5534-95-2
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Pentagastrin (ICI-50123) (ICI-50123) 是一种有效的选择性胆囊收缩素 B (CCKB) 受体拮抗剂,对 CCKB 和 CCKA 的 IC50 值分别为 11 nM 和 1100 nM。
Cas No.5534-95-2
别名五肽胃泌素; ICI-50123
Canonical SMILESO=C(N[C@@H](CCSC)C(N[C@@H](CC(O)=O)C(N[C@H](C(N)=O)CC1=CC=CC=C1)=O)=O)[C@@H](NC(CCNC(OC(C)(C)C)=O)=O)CC2=CNC3=C2C=CC=C3
分子式C37H49N7O9S
分子量767.89
溶解度DMSO : ≥ 34 mg/mL (44.28 mM)
储存条件-20°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

pentagastrin is a synthetic polypeptide that has effects like gastrin when given parenterally,which can cause the secretion and synthesis of salivary proteins.[1]In vivo: WIN55, 212-2, which is a non-selective cannabinoid agonist decreased gastric acid secretion stimulated by pentagastrin (10 mg/kg, i.v.) in anaesthetized rats.[2]The effect of curcumin administered i.g. in a dose of 50 mg/kg on the pentagastrin (250 ?g/kg)-stimulated gastric acid output in rats with chronic gastric fistula. [3]

[1]. Loy F et al. Ultrastructural evidence of a secretory role for melatonin in the human parotid gland.J Physiol Pharmacol, 2015 Dec, 66(6):847-53. [2]. Abdel-Salam O et al. Gastric acid inhibitory and gastric protective effects of Cannabis and cannabinoids. Asian Pac J Trop Med, 2016 May, 9(5):413-9. [3]. Czekaj R et al. Role of curcumin in protection of gastric mucosa against stress-induced gastric mucosal damage. Involvement of hypoacidity, vasoactive mediators and sensory neuropeptides. J Physiol Pharmacol, 2016 Apr, 67(2):261-75.