CAS NO: | 5908-99-6 |
包装 | 价格(元) |
10mM (in 1mL DMSO) | 电议 |
100mg | 电议 |
200mg | 电议 |
Physical Appearance | A solid |
Storage | Store at -20°C |
M.Wt | 694.83 |
Cas No. | 5908-99-6 |
Formula | 2(C17H23NO3)·H2O·H2SO4 |
Synonyms | Tropine |
Solubility | ≥34.74 mg/mL in DMSO; ≥56.5 mg/mL in H2O; ≥59.7 mg/mL in EtOH |
Chemical Name | [(1R,5S)-8-methyl-8-azabicyclo[3.2.1]octan-3-yl] 3-hydroxy-2-phenylpropanoate;sulfuric acid;hydrate |
Canonical SMILES | CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3.CN1C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3.O.OS(=O)(=O)O |
运输条件 | 蓝冰运输或根据您的需求运输。 |
一般建议 | 为了使其更好的溶解,请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异,仅做参考。若实验所需浓度过大至产品溶解极限,请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存,请尽快用完。 |
Atropine(阿托品)是毒蕈碱型乙酰胆碱受体的竞争性拮抗剂,对M1、M2、M3、M4和M5的IC50值分别为2.22 ± 0.60 nM、4.32 ± 1.63 nM、4.16 ± 1.04 nM、2.38 ± 1.07 nM和3.39 ± 1.16 nM[1]。
阿托品是一种抗毒蕈碱药物,研究表明,它可以与毒蕈碱乙酰胆碱受体结合,产生一定的药理作用。阿托品是一种正位拮抗剂,有报道表明,在所有毒蕈碱亚型中,它可以与[3H]-NMS竞争结合,对mAchR的亚型具有高亲和力。Ki值分别为1.27 ± 0.36 nM、3.24 ± 1.16 nM、2.21 ± 0.53 nM、0.77 ± 0.43 nM和2.84 ± 0.84 nM[1, 2, 3]。
参考文献:
[1] Lebois EP1, Bridges TM, Lewis LM, Dawson ES, Kane AS, Xiang Z, Jadhav SB, Yin H, Kennedy JP, Meiler J, Niswender CM, Jones CK, Conn PJ, Weaver CD, Lindsley CW. Discovery and characterization of novel subtype-selective allosteric agonists for the investigation of M(1) receptor function in the central nervous system.ACS Chem Neurosci. 2010;1(2):104-121.
[2] BUSCH H, ALLEN H, ANDERSON DC. Effects of atropine and carbachol on labeling of protein fractions of mouse pancreas in vitro.J Pharmacol Exp Ther. 1959 Nov; 127:200-4.
[3] Feron O1, Smith TW, Michel T, Kelly RA. Dynamic targeting of the agonist-stimulated m2 muscarinic acetylcholine receptor to caveolae in cardiac myocytes. J Biol Chem. 1997 Jul 11; 272(28):17744-8.