| CAS NO: | 186826-86-8 |
| 包装 | 价格(元) |
| 10mM (in 1mL DMSO) | 电议 |
| 50mg | 电议 |
| 200mg | 电议 |
| Physical Appearance | A solid |
| Storage | Store at -20°C |
| M.Wt | 437.89 |
| Cas No. | 186826-86-8 |
| Formula | C21H24FN3O4·HCl |
| Solubility | insoluble in EtOH; ≥19.15 mg/mL in DMSO; ≥25.4 mg/mL in H2O with gentle warming |
| Chemical Name | 7-[(4aS,7aS)-1,2,3,4,4a,5,7,7a-octahydropyrrolo[3,4-b]pyridin-6-yl]-1-cyclopropyl-6-fluoro-8-methoxy-4-oxoquinoline-3-carboxylic acid;hydrochloride |
| Canonical SMILES | COC1=C2C(=CC(=C1N3CC4CCCNC4C3)F)C(=O)C(=CN2C5CC5)C(=O)O.Cl |
| 运输条件 | 蓝冰运输或根据您的需求运输。 |
| 一般建议 | 为了使其更好的溶解，请用37℃加热试管并在超声波水浴中震动片刻。不同厂家不同批次产品溶解度各有差异，仅做参考。若实验所需浓度过大至产品溶解极限，请添加助溶剂助溶或自行调整浓度。溶液形式一般不宜长期储存，请尽快用完。 |
Moxifloxacin HCl（莫西沙星盐酸）是具有广谱抗菌活性的抗感染化合物[1]。
Moxifloxacin是第四代氟喹诺酮类抗菌剂，抗菌谱广，可以抗革兰氏阳性菌和革兰氏阴性菌[1]。Moxifloxacin的抗菌活性主要通过抑制DNA拓扑异构酶II和拓扑异构酶IV的活性，这两个拓扑异构酶参与细菌DNA的复制、转录、重组和修复[2]。Moxifloxacin的口服生物利用度可以高达90％。由于moxifloxacin不是肝细胞色素P-450同功酶系统的抑制剂或底物，所以它没有潜在的药物相互作用。Moxifloxacin有约90-97％的细菌清除率和88-97％的临床成功率。Ciprofloxacin（环丙沙星）敏感株中，Moxifloxacin的MIC90s小于等于 0.6 μg/mL。肠球菌中moxifloxacin的MIC90s范围为1至4 μg/mL。副流感嗜血杆菌中moxifloxacin的MIC90s从0.03到0.125 μg/ mL。其它细菌中moxifloxacin的MIC90s为4 μg/mL。脆弱拟杆菌中moxifloxacin的MIC90s为0.25-4 μg/mL[3]。
Moxifloxacin也抑制hPON1（人血清对氧磷酶-1）的酶活性，Ki值为2.641 ± 0.004 mM[4]。
参考文献：?
[1].?? ?Cruz LA, Hall R: Enantiomeric purity assay of moxifloxacin hydrochloride by capillary electrophoresis. J Pharm Biomed Anal 2005, 38(1):8-13.
[2].?? ?Kamruzzaman M, Alam AM, Lee SH, Ragupathy D, Kim YH, Park SR, Kim SH: Spectrofluorimetric study of the interaction between europium(III) and moxifloxacin in micellar solution and its analytical application. Spectrochim Acta A Mol Biomol Spectrosc 2012, 86:375-380.
[3].?? ?Culley CM, Lacy MK, Klutman N, Edwards B: Moxifloxacin: clinical efficacy and safety. Am J Health Syst Pharm 2001, 58(5):379-388.
[4].?? ?Turkes C, Soyut H, Beydemir S: Human serum paraoxonase-1 (hPON1): in vitro inhibition effects of moxifloxacin hydrochloride, levofloxacin hemihidrate, cefepime hydrochloride, cefotaxime sodium and ceftizoxime sodium. J Enzyme Inhib Med Chem 2014:1-7
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