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C-171
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
C-171图片
CAS NO:2244881-69-2
包装与价格：
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
C-171 是干扰素基因刺激物 (STING) 的抑制剂。
Cas No.2244881-69-2
化学名N-(4-hexylphenyl)-5-nitro-2-furancarboxamide
Canonical SMILESO=C(C1=CC=C([N+]([O-])=O)O1)NC2=CC=C(CCCCCC)C=C2
分子式C17H20N2O4
分子量316.4
溶解度DMF: 25 mg/ml,DMSO: 25 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

C-171 is an inhibitor of stimulator of interferon genes (STING).[1],[2] It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1.[1] It selectively reduces human and mouse STING-, but not RIG-I or TBK1-, mediated IFN-β reporter activity in HEK293 cells when used at concentrations ranging from 0.02 to 2 μM.

Reference:
[1].Haag, S.M., Gulen, M.F., Reymond, L., et al.Targeting STING with covalent small-molecule inhibitorsNature559(7713)269-273(2018)
[2].Zhang, H., You, Q.-D., and Xu, X.-L.Targeting stimulator of interferon genes (STING): A medicinal chemistry perspectiveJ. Med. Chem.63(8)3785-3816(2019)