CAS NO: | 346691-38-1 |
包装 | 价格(元) |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
Cas No. | 346691-38-1 |
Canonical SMILES | CCCCC1=CC=C(NC(C2=CC=C([N+]([O-])=O)O2)=O)C=C1 |
分子式 | C15H16N2O4 |
分子量 | 288.3 |
溶解度 | DMSO: Soluble |
储存条件 | Store at -20°C |
General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
产品描述 | C-170 is an inhibitor of stimulator of interferon genes (STING).1,2It binds to STING, inhibits its palmitoylation, and prevents the recruitment and phosphorylation of TBK1.1It selectively reduces human and mouse STING-, but not RIG-I- or TBK1-, mediated IFN-β reporter activity in HEK293 cells when used at concentrations ranging from 0.02 to 2 µM. 1.Haag, S.M., Gulen, M.F., Reymond, L., et al.Targeting STING with covalent small-molecule inhibitorsNature559(7713)269-273(2018) 2.Zhang, H., You, Q.-D., and Xu, X.-L.Targeting stimulator of interferon genes (STING): A medicinal chemistry perspectiveJ. Med. Chem.63(8)3785-3816(2019) |