您好，欢迎来到化工原料网！ [登录] [免费注册]
化工原料网
发布求购
位置：首页 > 产品库 > DK-AH 269
立即咨询
咨询类型：
     
*姓名：
*电话：
*单位：
Email：
*留言内容：
请详细说明您的需求。
*验证码：
 
DK-AH 269
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
DK-AH 269图片
CAS NO:186097-54-1
包装与价格：
包装价格(元)
1mg电议
5mg电议
10mg电议
25mg电议

产品介绍
西洛布雷定是一种 HCN 通道阻滞剂；神经元 Ih 和相关心脏 If 通道的开放通道阻滞剂。
Cas No.186097-54-1
别名西洛雷定盐酸盐,DK-AH 269
化学名3-[[(3S)-1-[2-(3,4-dimethoxyphenyl)ethyl]-3-piperidinyl]methyl]-1,3,4,5-tetrahydro-7,8-dimethoxy-2H-3-benzazepin-2-one, monohydrochloride
Canonical SMILESCOC1=CC=C(CCN2CC(CN(CCC(C=C(OC)C(OC)=C3)=C3C4)C4=O)CCC2)C=C1OC.Cl
分子式C28H38N2O5.HCl
分子量519.1
溶解度DMF: 3 mg/ml,DMSO: 3 mg/ml,Ethanol: 0.5 mg/ml,PBS (pH 7.2): 2 mg/ml
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

DK-AH 269 (Cilobradine) is an HCN Channel blocker; an open channel blocker of neuronal Ih and related cardiac If channels.
Target: HCN Channel blocker
DK-AH 269 is a HCN channel blocker that is about 3 times more potent than ZD7288. At a concentration of 10 μM, DK-AH 269 inhibits WT mHCN2 channel current by 86 ± 2% (n = 5). In contrast, I432A and A425G channel currents were only reduced by 14 ± 1% (n = 4) and 19 ± 2% (n = 8), respectively, by this concentration of DK-AH 269. The double mutant (I432A/A425G) channel was even less sensitive to 10 μM DK-AH 269 (8 ± 2% inhibition; n = 4).

References
[1]. Cheng L, et al. Molecular mapping of the binding site for a blocker of hyperpolarization-activated, cyclic nucleotide-modulated pacemaker channels. J Pharmacol Exp Ther. 2007 Sep;322(3):931-939.