| Cas No. | 883976-12-3 |
| 化学名 | N-(2-aminoethyl)-N-[[3-methoxy-4-(phenylmethoxy)phenyl]methyl]-2-thiophenecarboxamide, monohydrochloride |
| Canonical SMILES | COC(C=C(CN(C(C1=CC=CS1)=O)CCN)C=C2)=C2OCC3=CC=CC=C3.Cl |
| 分子式 | C22H24N2O3S.HCl |
| 分子量 | 433 |
| 溶解度 | DMF: 10 mg/ml,DMSO: 15 mg/ml,DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | M8-B is an antagonist of transient receptor potential melastatin 8 (TRPM8) that blocks activation by cold, icilin , or menthol in vitro (IC50s = 7.8, 26.9, and 64.3 nM, respectively). It displays no effect at other TRP channels. M8-B decreases deep body temperature in wild-type mice and rats but has no effect on body temperature in TRPM8 KO mice. |
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