Marinobufagenin 是已在哺乳动物血浆中鉴定的 Na+/K+ ATPase 的强抑制剂。
| Cas No. | 470-42-8 |
| 别名 | 南美蟾毒精 |
| 化学名 | (3β,5β,15β)-14,15-epoxy-3,5-dihydroxy-bufa-20,22-dienolide |
| Canonical SMILES | O[C@H]1CC[C@@]2(C)[C@@](CC[C@]3([H])[C@]2([H])CC[C@@]4(C)[C@]3(O5)[C@H]5C[C@@H]4C6=COC(C=C6)=O)(O)C1 |
| 分子式 | C24H32O5 |
| 分子量 | 400.5 |
| 溶解度 | DMF: 3 mg/ml,DMF:PBS (pH 7.2) (1:8): 0.1 mg/ml,Ethanol: 1 mg/ml |
| 储存条件 | Store at -20°C |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request |
| 产品描述 | Marinobufagenin (MBG) is a bufadienolide steroid first isolated from toads of genus Bufo. It can also be excreted by mammalian cells, particularly kidney cells from hypertensive animals. MBG inhibits the ouabain-resistant α1 Na+/K+ ATPase subunit (IC50 = 78 nM), impairing a major sodium pump of the kidneys, resulting in natriuresis and arterial hypertension. Serum and urine levels of MBG are also elevated after cardiac infarction, and a reduced form of MBG, marinobufotoxin, occurs in the plasma of patients with terminal renal failure. Through its effects on the α1 Na+/K+ ATPase subunit, MBG has profound immediate and prolonged effects on kidney, heart, and vascular functions. |
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